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na v 1 6 rb  (Alomone Labs)


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    Alomone Labs na v 1 6 rb
    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
    Na V 1 6 Rb, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 154 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/na+v+1+6/Anti-NaV1%2E6+Antibody/pmc12852067-6-0-5
    Average 96 stars, based on 154 article reviews
    na v 1 6 rb - by Bioz Stars, 2026-09
    96/100 stars

    Images

    1) Product Images from "Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment"

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    Journal: The Journal of Comparative Neurology

    doi: 10.1002/cne.70127

    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
    Figure Legend Snippet: Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.

    Techniques Used: Modification, Immunolabeling, Labeling

    Na V 1.2 labels Domain 3 in majority of afferents, first nodes, and stromal paranodes. (A, A’) Na V 1.2 ( green ) labels the calyx outer surfaces (Domain 3, arrows ) of D afferents in the extrastriolar zone of the utricular macula from an adult female rat. The calyx inner surfaces are marked with Caspr1 ( Caspr, red in A). The beginning of two parent axons (arrowheads) can be seen in the neuroepithelium, but could not be traced into the stroma, where the heminodes of most D units are located, presumably because they go out of the plane of this single section. Inset in A’, upper right , schematic of entire calyx, showing Domain 3 in red. (B) Na V 1.2 antibody ( green ) labels mostly stromal nodes ( arrowheads ), but not heminodes ( arrows ), both of which are marked with an ezrin antibody ( red ). (C) Deeper in the stroma of the crista in a maximum intensity projection, many nodes can be observed. The Na V 1.2 ( green ) extends beyond the boundaries of the node, marked by ezrin ( red ). C insets . Na V 1.6 antibody (in this case red ) immunostains two nodes of Ranvier in the stroma of a rat saccular macula. Similar to (C), Na V 1.2 ( green ) also stains the nodes (seen after removal of the Na V 1.6 immunolabel ( red ) in the bottom half of each inset) and extends well beyond each node into the paranode. Scale bars: A–C = 10 µm; C inset = 5 µm.
    Figure Legend Snippet: Na V 1.2 labels Domain 3 in majority of afferents, first nodes, and stromal paranodes. (A, A’) Na V 1.2 ( green ) labels the calyx outer surfaces (Domain 3, arrows ) of D afferents in the extrastriolar zone of the utricular macula from an adult female rat. The calyx inner surfaces are marked with Caspr1 ( Caspr, red in A). The beginning of two parent axons (arrowheads) can be seen in the neuroepithelium, but could not be traced into the stroma, where the heminodes of most D units are located, presumably because they go out of the plane of this single section. Inset in A’, upper right , schematic of entire calyx, showing Domain 3 in red. (B) Na V 1.2 antibody ( green ) labels mostly stromal nodes ( arrowheads ), but not heminodes ( arrows ), both of which are marked with an ezrin antibody ( red ). (C) Deeper in the stroma of the crista in a maximum intensity projection, many nodes can be observed. The Na V 1.2 ( green ) extends beyond the boundaries of the node, marked by ezrin ( red ). C insets . Na V 1.6 antibody (in this case red ) immunostains two nodes of Ranvier in the stroma of a rat saccular macula. Similar to (C), Na V 1.2 ( green ) also stains the nodes (seen after removal of the Na V 1.6 immunolabel ( red ) in the bottom half of each inset) and extends well beyond each node into the paranode. Scale bars: A–C = 10 µm; C inset = 5 µm.

    Techniques Used: Immunolabeling

    Na V 1.6 marks both nodes and heminodes, except for heminodes in calyx‐only afferents. Caspr1 ( Caspr, red ) labels the inner surface of calyces, the proximal (central) sides of heminodes (Domain 4, red in schematic, top left ) and in the paranodes on both sides of nodes in this maximum intensity projection image of a utricular macula. Note that all the nodes and most of the heminodes are labeled with Na V 1.6 ( green ), except for two heminodes ( arrows ), sitting just above the Caspr‐labeled hemi‐paranodes, presumably belonging to C fibers located above the basement membrane ( dashed line ). Scale bar = 5 µm.
    Figure Legend Snippet: Na V 1.6 marks both nodes and heminodes, except for heminodes in calyx‐only afferents. Caspr1 ( Caspr, red ) labels the inner surface of calyces, the proximal (central) sides of heminodes (Domain 4, red in schematic, top left ) and in the paranodes on both sides of nodes in this maximum intensity projection image of a utricular macula. Note that all the nodes and most of the heminodes are labeled with Na V 1.6 ( green ), except for two heminodes ( arrows ), sitting just above the Caspr‐labeled hemi‐paranodes, presumably belonging to C fibers located above the basement membrane ( dashed line ). Scale bar = 5 µm.

    Techniques Used: Labeling, Membrane

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    Incubation:

    Article Title: The X‐Linked Intellectual Disability Gene, ZDHHC9 , Is Important for Oligodendrocyte Subtype Determination and Myelination
    Article Snippet: .. The sections were then incubated in PBS‐TX with 5% goat serum containing primary antibodies for Na v 1.6 (1:500 dilution, ASC‐009, Alomone); or Olig2 (1:500, NBP1‐28667, Novus) and CC‐1 (1:100, ab16794, Abcam); or GFAP (1:500, ab7260, Abcam) and Iba1 (1:500, ab178846, Abcam); or Olig2 (1:500, NBP1‐28667, Novus) and Ki67 (1:500, ab15580, Abcam); or Olig2 (1:500, NBP1‐28667, Novus) and CC3 (1:500, 9661S, Cell Signaling Techno) were incubated overnight at 4 ° C. Following primary antibody incubation, sections were washed in PBS‐TX (3 × 5 min) and incubated in PBS‐TX containing secondary goat anti‐rabbit AlexaFluor 488 (1:500 dilution, Ab150077 , Abcam) or goat anti‐mouse AlexaFluor 488 (1:500, A‐21141, Invitrogen) and goat anti‐rabbit AlexaFluor 647 (1:500, A‐21244, Invitrogen). .. Sections were then washed in PBS‐TX (3 × 5 min) and counter‐stained with DAPI (1:500) in PBS‐TX for 10 min. Lastly, sections were washed in PBS (3 × 5 min), mounted onto Superfrost Plus glass slides (Fisher Scientific), and coverslips were applied using the ProLong Gold anti‐fade (Invitrogen) mounting medium.

    Article Title: Genetically engineered MAPT 10+16 mutation causes pathophysiological excitability of human iPSC-derived neurons related to 4R tau-induced dementia
    Article Snippet: Protein was fractionated on SDS polyacrylamide gel (ThermoFisher, UK) and transferred to a PVDF membrane (Bio-Rad, Richmond, CA). .. The primary antibodies were: Na v 1.6 (1:500, Alomone Labs, Jerusalem, Israel, ASC-009) and β-tubulin III (1:5000, Cell Signaling Technologies, MA, USA, MAB1195) diluted in 5% BSA and incubated overnight. .. After incubation with the secondary antibodies (for 1 h), the luminol-based PierceTM ECL Western Blotting Substrate (ThermoFisher Scientific) was used to detect HRP activity.

    Article Title: Molecular and functional characterization of voltage-gated sodium channels in human sperm
    Article Snippet: .. Test slides were incubated with a primary polyclonal antibody designed to recognize Na v 1.1 (sc-16031, goat), Na v 1.2 (sc-28753, rabbit), Na v 1.3 (sc-22202, goat), Na v 1.4 (sc-28751, rabbit) and Na v 1.5 (sc-22758, rabbit), from Santa Cruz Biotechnology (Santa Cruz, CA); Na v 1.6 (asc-009, rabbit) from Alomone Labs (Jerusalem, Israel); Na v 1.7 (ab-65167, rabbit), Na v 1.8 (ab-66743, rabbit), Na v 1.9 (ab-65160, rabbit) and Na x (ab-66499, rabbit), from Abcam (Cambridge, UK). ..

    Knock-Out:

    Article Title: Schwann cells promote sensory neuron excitability during development
    Article Snippet: .. Antibodies used in this study include the following: Neurofilament (Sigma-Aldrich, N4142, 1:1000), goat anti-rabbit IgG polyclonal antibody (CFTM 405M, 20181, 1:1000), Ptges3 (knockout validated, Origene technologies, TA803433, 1:1000), Mbp (knockout validated , Abcam, ab7349, 1:100), Na v 1.8 (knockout validated, Neuromab, SKU 75-166, 1:1000 for cultured cells, 1:200 for tissues [ ]), Na v 1.7 (knockout validated , Neuromab, SKU 75-103, 1:200 for tissues [ ]), Na v 1.1 (knockout validated , Alomone Labs, Asc-001, 1:1000), Na v 1.2 (knockout validated , Alomone Labs, Asc-002, 1:1000), Na v 1.6 (knockout validated , Alomone Labs, Asc-009, 1:1000), Na v 1.7 (knockout validated , Alomone Labs, Asc-008, 1:1000 for cultured cells, 1:200 for tissues [ ]), Na v 1.8 (knockout validated , Alomone Labs, ASC-016, 1:200 for tissues [ ]), Na v 1.5, knockout validated , Alomone Labs, ASC-005, 1:1000), Na v 1.9, Alomone Labs, AGP-030, 1:1000), and highly cross-absorbed Alexa Fluor 488-, 594-, or 647-labeled secondary antibodies (Thermo Fisher). ..

    Cell Culture:

    Article Title: Schwann cells promote sensory neuron excitability during development
    Article Snippet: .. Antibodies used in this study include the following: Neurofilament (Sigma-Aldrich, N4142, 1:1000), goat anti-rabbit IgG polyclonal antibody (CFTM 405M, 20181, 1:1000), Ptges3 (knockout validated, Origene technologies, TA803433, 1:1000), Mbp (knockout validated , Abcam, ab7349, 1:100), Na v 1.8 (knockout validated, Neuromab, SKU 75-166, 1:1000 for cultured cells, 1:200 for tissues [ ]), Na v 1.7 (knockout validated , Neuromab, SKU 75-103, 1:200 for tissues [ ]), Na v 1.1 (knockout validated , Alomone Labs, Asc-001, 1:1000), Na v 1.2 (knockout validated , Alomone Labs, Asc-002, 1:1000), Na v 1.6 (knockout validated , Alomone Labs, Asc-009, 1:1000), Na v 1.7 (knockout validated , Alomone Labs, Asc-008, 1:1000 for cultured cells, 1:200 for tissues [ ]), Na v 1.8 (knockout validated , Alomone Labs, ASC-016, 1:200 for tissues [ ]), Na v 1.5, knockout validated , Alomone Labs, ASC-005, 1:1000), Na v 1.9, Alomone Labs, AGP-030, 1:1000), and highly cross-absorbed Alexa Fluor 488-, 594-, or 647-labeled secondary antibodies (Thermo Fisher). ..

    other:

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    Article Snippet: The following antibodies were used in this study: Na V 1.2 (NeuroMab/Antibodies Incorporated #75-024), Na V 1.6 (Alomone Labs #ASC-009 and NeuroMab/Antibodies Incorporated #73-026), Pan-Nav (Sigma, #S8809), AnkG (Life technologies #33-8800, Neuromab/Antibodies Incorporated #75-146 and Synaptic systems #386-005), βIV-spectrin (Biotrend, provided by Maren Engelhardt, Johnnes-Kepler-University, Linz, Austria), MAP2 (Abcam/Bio Connect #ab5392), GFP (MBL International/Sanbio #598 and Abcam #ab13970).Corresponding secondary antibodies Alexa-conjugated 405, 488, 568, 594 or 647 goat anti-mouse, anti-mouse IgG1/IgG2a, anti-rabbit, anti guinea-pig or anti-chicken were used (Life Technologies), as well as streptavidin Alexa-633 conjugate (Life Technologies) for the detection of biocytin filled neurons.



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    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
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    Alomone Labs na v 1 6
    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
    Na V 1 6, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/na+v+1+6/Anti-NaV1%2E6+Antibody/pmc12121472-83-15-21
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    na v 1 6 - by Bioz Stars, 2026-09
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    rabbit anti na v 1 6  (Alomone Labs)
    96
    Alomone Labs rabbit anti na v 1 6
    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
    Rabbit Anti Na V 1 6, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/na+v+1+6/Anti-Nav1%2E6+(SCN8A)+Antibody/pmc11708877-348-36-41
    Average 96 stars, based on 1 article reviews
    rabbit anti na v 1 6 - by Bioz Stars, 2026-09
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    cd4 na v 1 6 nluc  (Santa Cruz Biotechnology)
    97
    Santa Cruz Biotechnology cd4 na v 1 6 nluc
    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
    Cd4 Na V 1 6 Nluc, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/na+v+1+6/GSK-3%CE%B2/pmc11847078-262-5-24
    Average 97 stars, based on 1 article reviews
    cd4 na v 1 6 nluc - by Bioz Stars, 2026-09
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    antibodies against na v 1 6  (Alomone Labs)
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    Alomone Labs antibodies against na v 1 6
    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.
    Antibodies Against Na V 1 6, supplied by Alomone Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/na+v+1+6/Anti-NaV1%2E6+(SCN8A)+Antibody/pmc11544082-243-12-19
    Average 96 stars, based on 1 article reviews
    antibodies against na v 1 6 - by Bioz Stars, 2026-09
    96/100 stars
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    Image Search Results


    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.

    Article Snippet: Na V 1.6 (rb)/(ms) , Rasband/NeuroMab , gift, 75‐026 RRID:AB_2184197 , X (if) , X (ON, Br) , , X , , Rasband et al. ( ); datasheet .

    Techniques: Modification, Immunolabeling, Labeling

    Na V 1.2 labels Domain 3 in majority of afferents, first nodes, and stromal paranodes. (A, A’) Na V 1.2 ( green ) labels the calyx outer surfaces (Domain 3, arrows ) of D afferents in the extrastriolar zone of the utricular macula from an adult female rat. The calyx inner surfaces are marked with Caspr1 ( Caspr, red in A). The beginning of two parent axons (arrowheads) can be seen in the neuroepithelium, but could not be traced into the stroma, where the heminodes of most D units are located, presumably because they go out of the plane of this single section. Inset in A’, upper right , schematic of entire calyx, showing Domain 3 in red. (B) Na V 1.2 antibody ( green ) labels mostly stromal nodes ( arrowheads ), but not heminodes ( arrows ), both of which are marked with an ezrin antibody ( red ). (C) Deeper in the stroma of the crista in a maximum intensity projection, many nodes can be observed. The Na V 1.2 ( green ) extends beyond the boundaries of the node, marked by ezrin ( red ). C insets . Na V 1.6 antibody (in this case red ) immunostains two nodes of Ranvier in the stroma of a rat saccular macula. Similar to (C), Na V 1.2 ( green ) also stains the nodes (seen after removal of the Na V 1.6 immunolabel ( red ) in the bottom half of each inset) and extends well beyond each node into the paranode. Scale bars: A–C = 10 µm; C inset = 5 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: Na V 1.2 labels Domain 3 in majority of afferents, first nodes, and stromal paranodes. (A, A’) Na V 1.2 ( green ) labels the calyx outer surfaces (Domain 3, arrows ) of D afferents in the extrastriolar zone of the utricular macula from an adult female rat. The calyx inner surfaces are marked with Caspr1 ( Caspr, red in A). The beginning of two parent axons (arrowheads) can be seen in the neuroepithelium, but could not be traced into the stroma, where the heminodes of most D units are located, presumably because they go out of the plane of this single section. Inset in A’, upper right , schematic of entire calyx, showing Domain 3 in red. (B) Na V 1.2 antibody ( green ) labels mostly stromal nodes ( arrowheads ), but not heminodes ( arrows ), both of which are marked with an ezrin antibody ( red ). (C) Deeper in the stroma of the crista in a maximum intensity projection, many nodes can be observed. The Na V 1.2 ( green ) extends beyond the boundaries of the node, marked by ezrin ( red ). C insets . Na V 1.6 antibody (in this case red ) immunostains two nodes of Ranvier in the stroma of a rat saccular macula. Similar to (C), Na V 1.2 ( green ) also stains the nodes (seen after removal of the Na V 1.6 immunolabel ( red ) in the bottom half of each inset) and extends well beyond each node into the paranode. Scale bars: A–C = 10 µm; C inset = 5 µm.

    Article Snippet: Na V 1.6 (rb)/(ms) , Rasband/NeuroMab , gift, 75‐026 RRID:AB_2184197 , X (if) , X (ON, Br) , , X , , Rasband et al. ( ); datasheet .

    Techniques: Immunolabeling

    Na V 1.6 marks both nodes and heminodes, except for heminodes in calyx‐only afferents. Caspr1 ( Caspr, red ) labels the inner surface of calyces, the proximal (central) sides of heminodes (Domain 4, red in schematic, top left ) and in the paranodes on both sides of nodes in this maximum intensity projection image of a utricular macula. Note that all the nodes and most of the heminodes are labeled with Na V 1.6 ( green ), except for two heminodes ( arrows ), sitting just above the Caspr‐labeled hemi‐paranodes, presumably belonging to C fibers located above the basement membrane ( dashed line ). Scale bar = 5 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: Na V 1.6 marks both nodes and heminodes, except for heminodes in calyx‐only afferents. Caspr1 ( Caspr, red ) labels the inner surface of calyces, the proximal (central) sides of heminodes (Domain 4, red in schematic, top left ) and in the paranodes on both sides of nodes in this maximum intensity projection image of a utricular macula. Note that all the nodes and most of the heminodes are labeled with Na V 1.6 ( green ), except for two heminodes ( arrows ), sitting just above the Caspr‐labeled hemi‐paranodes, presumably belonging to C fibers located above the basement membrane ( dashed line ). Scale bar = 5 µm.

    Article Snippet: Na V 1.6 (rb)/(ms) , Rasband/NeuroMab , gift, 75‐026 RRID:AB_2184197 , X (if) , X (ON, Br) , , X , , Rasband et al. ( ); datasheet .

    Techniques: Labeling, Membrane

    Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: Nodal protein‐like immunoreactivity reveals heminodes and first nodes on the distal process of vestibular afferents. (A) Schematic of calyceal microdomains (modified from Lysakowski et al. ). (B) β‐IV spectrin ( B‐IV Spec , red ) labels heminodes (Domain 4) and nodes in vestibular afferents and the upper portion of the calyx (Domain 2, asterisks ) in dimorphic afferents (indicated by a lack of calretinin ( Calret ) immunolabel, green ). (C,D) Neurofascin‐186 ( NF‐186 , red) labels heminodes ( arrows ) and nodes in crista ( C ) and otolith ( D ) organs. (E) Na V 1.6 ( green ), the most common nodal Na channel isoform, is present at the heminode, while Caspr ( red ) labels the hemi‐paranode ( brackets ). In the right half of this panel, myelin basic protein ( MBP , blue ) extends over the hemi‐paranode to the heminode. (F) Two different examples of ezrin labeling ( red ). Ezrin labels the heminode, MBP ( blue ) labels the internode, and there is a small gap between them as the myelin attenuates, the hemi‐paranode ( brackets , not immunolabeled here, but seen in panel ( E ), labeled with Caspr, red ). (G, H) qPCR demonstrates the presence of Na V 1.6 ( G ) and Na V 1.5 ( H ) in vestibular ganglion ( VG ) cells ( G, H ), but to a lesser extent in the vestibular ( VO ) and cochlear ( CO ) sensory organs. Brain ( Br ) and heart ( H ) served as controls for Na V 1.6 and Na V 1.5, respectively. Values are means ± SEM. (I, I’) Ezrin ( red ) and AnkG ( green ) are seen to be co‐extensive in a rat vestibular nerve node, while ezrin and AnkB (J, J’) are complementary, with ezrin ( red ) labeling the node and AnkB ( green ) the paranode. (K) Vestibular ganglion cell labeled with calretinin ( green ) and Ank G ( red ) labeling the first proximal node of Ranvier ( arrow ). Scale bars: in B‐D, K = 10 µm; in E (also applies to F, I, J) = 2 µm.

    Article Snippet: Na V 1.6 (rb) , Alomone , ASC‐009 RRID:AB_2040202 , , X (SN, Br, DRG) , , X , X (w, if) , Black et al. ( ) .

    Techniques: Modification, Immunolabeling, Labeling

    Na V 1.2 labels Domain 3 in majority of afferents, first nodes, and stromal paranodes. (A, A’) Na V 1.2 ( green ) labels the calyx outer surfaces (Domain 3, arrows ) of D afferents in the extrastriolar zone of the utricular macula from an adult female rat. The calyx inner surfaces are marked with Caspr1 ( Caspr, red in A). The beginning of two parent axons (arrowheads) can be seen in the neuroepithelium, but could not be traced into the stroma, where the heminodes of most D units are located, presumably because they go out of the plane of this single section. Inset in A’, upper right , schematic of entire calyx, showing Domain 3 in red. (B) Na V 1.2 antibody ( green ) labels mostly stromal nodes ( arrowheads ), but not heminodes ( arrows ), both of which are marked with an ezrin antibody ( red ). (C) Deeper in the stroma of the crista in a maximum intensity projection, many nodes can be observed. The Na V 1.2 ( green ) extends beyond the boundaries of the node, marked by ezrin ( red ). C insets . Na V 1.6 antibody (in this case red ) immunostains two nodes of Ranvier in the stroma of a rat saccular macula. Similar to (C), Na V 1.2 ( green ) also stains the nodes (seen after removal of the Na V 1.6 immunolabel ( red ) in the bottom half of each inset) and extends well beyond each node into the paranode. Scale bars: A–C = 10 µm; C inset = 5 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: Na V 1.2 labels Domain 3 in majority of afferents, first nodes, and stromal paranodes. (A, A’) Na V 1.2 ( green ) labels the calyx outer surfaces (Domain 3, arrows ) of D afferents in the extrastriolar zone of the utricular macula from an adult female rat. The calyx inner surfaces are marked with Caspr1 ( Caspr, red in A). The beginning of two parent axons (arrowheads) can be seen in the neuroepithelium, but could not be traced into the stroma, where the heminodes of most D units are located, presumably because they go out of the plane of this single section. Inset in A’, upper right , schematic of entire calyx, showing Domain 3 in red. (B) Na V 1.2 antibody ( green ) labels mostly stromal nodes ( arrowheads ), but not heminodes ( arrows ), both of which are marked with an ezrin antibody ( red ). (C) Deeper in the stroma of the crista in a maximum intensity projection, many nodes can be observed. The Na V 1.2 ( green ) extends beyond the boundaries of the node, marked by ezrin ( red ). C insets . Na V 1.6 antibody (in this case red ) immunostains two nodes of Ranvier in the stroma of a rat saccular macula. Similar to (C), Na V 1.2 ( green ) also stains the nodes (seen after removal of the Na V 1.6 immunolabel ( red ) in the bottom half of each inset) and extends well beyond each node into the paranode. Scale bars: A–C = 10 µm; C inset = 5 µm.

    Article Snippet: Na V 1.6 (rb) , Alomone , ASC‐009 RRID:AB_2040202 , , X (SN, Br, DRG) , , X , X (w, if) , Black et al. ( ) .

    Techniques: Immunolabeling

    Na V 1.6 marks both nodes and heminodes, except for heminodes in calyx‐only afferents. Caspr1 ( Caspr, red ) labels the inner surface of calyces, the proximal (central) sides of heminodes (Domain 4, red in schematic, top left ) and in the paranodes on both sides of nodes in this maximum intensity projection image of a utricular macula. Note that all the nodes and most of the heminodes are labeled with Na V 1.6 ( green ), except for two heminodes ( arrows ), sitting just above the Caspr‐labeled hemi‐paranodes, presumably belonging to C fibers located above the basement membrane ( dashed line ). Scale bar = 5 µm.

    Journal: The Journal of Comparative Neurology

    Article Title: Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

    doi: 10.1002/cne.70127

    Figure Lengend Snippet: Na V 1.6 marks both nodes and heminodes, except for heminodes in calyx‐only afferents. Caspr1 ( Caspr, red ) labels the inner surface of calyces, the proximal (central) sides of heminodes (Domain 4, red in schematic, top left ) and in the paranodes on both sides of nodes in this maximum intensity projection image of a utricular macula. Note that all the nodes and most of the heminodes are labeled with Na V 1.6 ( green ), except for two heminodes ( arrows ), sitting just above the Caspr‐labeled hemi‐paranodes, presumably belonging to C fibers located above the basement membrane ( dashed line ). Scale bar = 5 µm.

    Article Snippet: Na V 1.6 (rb) , Alomone , ASC‐009 RRID:AB_2040202 , , X (SN, Br, DRG) , , X , X (w, if) , Black et al. ( ) .

    Techniques: Labeling, Membrane